The Oklahoma Shared Clinical and Translational Resources

The OSCTR is funded by the National Institutes of Health as part of its IDeA-CTR program. We have the mission to serve as a catalyst for clinical and translational research that improves health and healthcare for Oklahomans, to provide training and infrastructure to help junior investigators to launch independent research careers, and to expand the opportunities of IDeA states and Oklahoma communities to participate in research that improves the health of our residents. 

Oklahoma Clinical and Translational Science Institute

 

OCTSI is the home of the OSCTR, as well as clinical research services and dissemination and implementation resources to help improve the delivery of healthcare. 

Oklahoma Primary Healthcare Improvement Cooperative

 

OPHIC is the implementation science arm of a statewide network to help improve healthcare delivery assisting primary care practices to adopt evidence-based best practices for the care of their patients.

OCTSI Clinical Research Unit

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The OCTSI CRU assists medical providers to identify and conduct clinical research opportunities in Oklahoma.

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Recent Publications

Impact of Preexisting Rare Diseases on COVID-19 Severity, Reinfection, and Long COVID, and the Modifying Effects of Vaccination and Antiviral Therapy: A Retrospective Study from the N3C Data Enclave

medRxiv [Preprint]. 2025 Jul 10:2025.07.09.25331138. doi: 10.1101/2025.07.09.25331138.

ABSTRACT

BACKGROUND: Over 10,000 rare diseases (RDs) affect more than 300 million people globally, yet their influence on COVID-19 severity, reinfection risk, and long COVID remains poorly understood. This study evaluates the impact of RDs on these outcomes and examines the effectiveness of vaccination and antiviral treatments among individuals with and without RDs.

Use of flavored and modified risk smokeless tobacco products among American Indian adults

Nicotine Tob Res. 2025 Feb 26:ntaf047. doi: 10.1093/ntr/ntaf047. Online ahead of print.

ABSTRACT

INTRODUCTION: Little is known about the use of modified risk smokeless tobacco products (MRSTP) and flavored smokeless tobacco (ST) products among American Indians (AI). Aim of this study is to evaluate differences in tobacco use characteristics, ST dependence, and cotinine levels according to the use of flavored ST and MRSTP among AI ST users.

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