The Oklahoma Shared Clinical and Translational Resources

The OSCTR is funded by the National Institutes of Health as part of its IDeA-CTR program. We have the mission to serve as a catalyst for clinical and translational research that improves health and healthcare for Oklahomans, to provide training and infrastructure to help junior investigators to launch independent research careers, and to expand the opportunities of IDeA states and Oklahoma communities to participate in research that improves the health of our residents. 

Oklahoma Clinical and Translational Science Institute

 

OCTSI is the home of the OSCTR, as well as clinical research services and dissemination and implementation resources to help improve the delivery of healthcare. 

Oklahoma Primary Healthcare Improvement Cooperative

 

OPHIC is the implementation science arm of a statewide network to help improve healthcare delivery assisting primary care practices to adopt evidence-based best practices for the care of their patients.

OCTSI Clinical Research Unit

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The OCTSI CRU assists medical providers to identify and conduct clinical research opportunities in Oklahoma.

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Citing the OSCTR

University of Oklahoma Health Sciences Receives Federal Funding to Improve Health Care Access Across the State

Submitted by alex on

Across large areas of Oklahoma and the nation, primary care clinics are a lifeline, providing care for people who otherwise would have to travel many miles to see a doctor. To increase access to vital health care, the National Institutes of Health announced an ambitious new initiative to integrate NIH-funded clinical trials into routine patient care in areas like rural Oklahoma and within Tribal nations.

OU Awarded $17 Million NIH Grant to Improve Cancer Outcomes Among Native Americans

Submitted by Anonymous (not verified) on

The National Institutes of Health has awarded the University of Oklahoma a five-year, $17.2 million grant to partner with tribal nations and communities to improve cancer outcomes. Research has shown that the American Indian and Alaska Native population in Oklahoma experiences a 36% higher incidence of cancer and a 73% higher death rate from cancer than faced by the U.S. general population.

Plasma Exosomes Show Promise for Early Detection of Pancreatic Cancer

Submitted by Anonymous (not verified) on

Pancreatic cancer is the fourth leading cause of cancer deaths in the United States, and pancreatic cancer has some of the lowest 5-year survival rates of any cancer. Early detection can improve survival rates. When pancreatic ductal adenocarcinoma is initially diagnosed at stage IV, patients have a 2.7% 5-year survival rate. When diagnosis occurs at Stage I or IIA, this improves to 34%. However, there are currently no accurate blood tests for early detection of pancreatic cancer.

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Recent Publications

GLP Medications and Severe Post-COVID-19 Outcomes Among Individuals with Type 2 Diabetes Mellitus

medRxiv [Preprint]. 2026 Jul 6:2026.07.03.26357246. doi: 10.64898/2026.07.03.26357246.

ABSTRACT

BACKGROUND: Glucagon-like peptide-1 receptor agonist-based therapies (GLP) have recently emerged as promising treatments across a wide range of health conditions. These medications may have protective effects against severe long-term consequences of COVID-19 by promoting weight loss, exerting antihyperglycemic and anti-inflammatory effects, and providing cardiovascular and endothelial protection.

The Burden of Obesity-Related Cancers in Oklahoma: Trends, Demographics, and Spatial Patterns

J Okla State Med Assoc. 2026 Jan-Feb;119(1):7-16.

ABSTRACT

BACKGROUND: Obesity is a growing public health crisis in the United States, with over 70% of adults classified as overweight or obese. It has been associated with multiple health conditions, including at least 13 types of cancer. Despite this, awareness of the obesity-cancer link remains low, with only 53% of Americans aware of it as of 2019. Understanding the epidemiology of obesity-related cancers is critical, particularly in high-obesity states like Oklahoma.

Demographic and Socioeconomic Factors Associated with Oral Health-Related Quality of Life among American Indian/Alaska Native Adults: Analysis of the Tribal Behavioral Risk Factor Surveillance System

J Racial Ethn Health Disparities. 2026 Jul 27. doi: 10.1007/s40615-026-03126-4. Online ahead of print.

ABSTRACT

Characterizing the Burden of Tobacco-Associated Cancers in Oklahoma: A Demographic and Geographic Perspective, 2018-2022

J Okla State Med Assoc. 2026 Mar-Apr;119(2):48-55.

ABSTRACT

BACKGROUND: Despite declining national smoking rates, Oklahoma continues to experience high tobacco use, particularly among groups such as American Indian/Alaska Native (AI/AN) and rural populations. Cigarette smoking is a leading cause of cancer, and tobacco-related cancer incidence remains a significant public health concern in Oklahoma.

Discrimination experiences are associated with same-day and next-day smoking among adults with low socio-economic status trying to quit: A secondary analysis of data from a randomized clinical trial

Addiction. 2026 Apr 30. doi: 10.1111/add.70419. Online ahead of print.

ABSTRACT

BACKGROUND AND AIMS: Research indicates that experiencing discrimination may be associated with a return to smoking following a quit attempt. The current study aimed to characterize day-to-day relations between discrimination and smoking in the context of a smoking cessation trial for adults with socio-economic disadvantage.

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