Thermomechanical data of polyurethane shape memory polymer: Considering varying compositions

3 weeks 5 days ago
Hailey Fisher
This article presents data from the investigation of the thermal characteristics and mechanical behaviors of twelve different compositions of a polyurethane shape memory polymer (SMP). Each of the SMP compositions has a unique molar ratio of three monomers: (i) hexamethylene diisocyanate (HDI), (ii) N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine (HPED), and (iii) Triethanolamine (TEA). The thermal characteristic datasets for each composition include the glass transition temperatures, as...

TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNα production

4 weeks ago
Michelle L Ratliff
The DNA binding protein AT-rich interacting domain 3a (ARID3a)² is expressed in healthy human hematopoietic cord blood progenitors where its modulation influences myeloid versus B lineage development. ARID3a is also variably expressed in subsets of adult peripheral blood hematopoietic progenitors where the consequences of ARID3a expression are unknown. In B lymphocytes, Toll-like receptor (TLR)³ signaling induces ARID3a expression in association with Type I interferon inflammatory cytokines. We...

Drs. Rasmussen and Scofield reply

1 month 1 week ago
Astrid Rasmussen
The cardinal laboratory/pathological features of Sjögren syndrome (SS) are autoantibodies (anti-Ro/SSA and anti-La/SSB) and lymphocytic infiltrate of the salivary glands. The lymphocytic infiltrate is graded by the focus score (FS) 1, 2, which is the number of foci with ≥ 50 lymphocytes per 4 mm² Much has been published about the clinical and laboratory differences found among Sjögren patients with and without autoantibodies, with the presence of anti-Ro generally associated with more severe...

Drs. Rasmussen and Scofield reply

1 month 1 week ago
Astrid Rasmussen
Cafaro and colleagues¹ have studied focus score (FS)-negative (that is, < 1 focus of ≥ 50 lymphocytes per 4 mm²) to FS-positive (≥ 1 focus per 4 mm²) Sjögren syndrome (SS) patients² in a manner similar to our recent study³ As in our study, there was evidence of B cell hyperreactivity among those subjects with a positive minor salivary gland biopsy, although the details of this finding varied between the 2 studies.

Disease Progression in Patients with Autosomal Dominant Retinitis Pigmentosa due to a Mutation in Inosine Monophosphate Dehydrogenase 1 (IMPDH1)

2 months ago
Lea D Bennett
CONCLUSIONS: There was variability in disease severity at the first visit, but results show that the peripheral retina is more susceptible to the deleterious consequences of an IMPDH1 mutation. Given the pattern of degeneration and the alternatively spliced isoforms of IMPDH1, potential interventions may consider targeting the periphery early in disease, modulating transcript expression, and/or preserving central vision at late stages of the disease.

Resting-state functional magnetic resonance imaging with independent component analysis for presurgical seizure onset zone localization: A systematic review and meta-analysis

2 months 2 weeks ago
Arpan R Chakraborty
OBJECTIVE: One of the greatest challenges of achieving successful surgical outcomes in patients with epilepsy is the ability to properly localize the seizure onset zone (SOZ). Many techniques exist for localizing the SOZ, including intracranial electroencephalography, magnetoencephalography, and stereoelectroencephalography. Recently, resting-state functional magnetic resonance imaging (rs-fMRI) in conjunction with independent component analysis (ICA) has been utilized for presurgical planning...

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications

2 months 3 weeks ago
Joan T Merrill
Reports of widespread thromboses and disseminated intravascular coagulation (DIC) in patients with coronavirus disease 19 (COVID-19) have been rapidly increasing in number. Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). This disorder is not typical DIC....

Validity of Medical Record Abstraction and Electronic Health Record-Generated Reports to Assess Performance on Cardiovascular Quality Measures in Primary Care

2 months 3 weeks ago
Juell Homco
CONCLUSIONS AND RELEVANCE: Ensuring valid performance measurement is critical for value-based payment models and quality improvement activities in primary care. This study found that extracting information for the same individuals using different data sources generated different performance score estimates. Further research is required to identify the sources of these differences.

Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies

3 months 1 week ago
Hemangi B Shah
Clostridioides difficile is a leading cause of nosocomial infection responsible for significant morbidity and mortality with limited options for therapy. Secreted C. difficile toxin B (TcdB) is a major contributor to disease pathology, and select TcdB-specific Abs may protect against disease recurrence. However, the high frequency of recurrence suggests that the memory B cell response, essential for new Ab production following C. difficile reexposure, is insufficient. We therefore isolated...

Sjögren's Syndrome Minor Salivary Gland CD4<sup>+</sup> Memory T Cells Associate with Glandular Disease Features and have a Germinal Center T Follicular Helper Transcriptional Profile

3 months 1 week ago
Michelle L Joachims
To assess the types of salivary gland (SG) T cells contributing to Sjögren's syndrome (SS), we evaluated SG T cell subtypes for association with disease features and compared the SG CD4^(+) memory T cell transcriptomes of subjects with either primary SS (pSS) or non-SS sicca (nSS). SG biopsies were evaluated for proportions and absolute numbers of CD4^(+) and CD8^(+) T cells. SG memory CD4^(+) T cells were evaluated for gene expression by microarray. Differentially-expressed genes were...

Sjögren Syndrome and Cancer

3 months 2 weeks ago
Ann Igoe
The association between malignancy and rheumatic diseases has been demonstrated in a multitude of studies. Little is understood regarding the pathogenesis of rheumatic and musculoskeletal diseases in association with malignancy. There is strong evidence regarding the association between Sjögren syndrome and lymphoma as well as risk factors for development of lymphoma in these patients. This article discusses the accumulating data on various malignancies described in primary Sjögren syndrome,...
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